Core Efficacy

Weight Management

Significant Weight Loss: In obese mouse models, approximately 12% weight loss was achieved within one month without affecting normal appetite and food intake (unlike traditional weight loss drugs).

Fat Reduction and Muscle Gain: Selectively reduces fat cell volume while maintaining lean muscle mass, improving body fat percentage.

Reduced Fat Accumulation: Reduced fat gain by 10 times in obese mice on a high-fat diet.

Improved Metabolic Health

Enhanced Energy Metabolism: Increased resting energy expenditure and promoted fat oxidation (fat burning).

Improved Insulin Sensitivity: Improved glycemic control and reduced risk of metabolic syndrome.

Improved Fatty Liver: Reduced liver fat content, showing therapeutic potential for non-alcoholic fatty liver disease (NAFLD).

Improved Performance and Muscle Strength

Enhanced Endurance: Running time increased by 70% in normal-weight mice and by 45% in obese mice, without actual training.

Improved Muscle Mass: Increased anti-fatigue IIa... SLU-PP-332 promotes the production of oxidative muscle fibers, increasing mitochondrial density and function in muscles.

It also enhances muscle recovery, reducing post-exercise fatigue, shortening recovery time, and supporting high-intensity training.

Other potential benefits include:

Cardiovascular health support: improving vascular function and cardiometabolism;

Cognitive enhancement: potentially having neuroprotective effects, supporting brain health and memory;

Anti-aging effects: potentially extending healthy lifespan by improving mitochondrial function and cellular energy metabolism.

Mechanism of action: SLU-PP-332 is a selective estrogen-related receptor (ERR) agonist, primarily activating three subtypes: ERRα, ERRβ, and ERRγ, with EC50 values of 98 nM, 230 nM, and 430 nM, respectively.

Its pathway of action is similar to exercise but does not require actual exercise:

Activating mitochondrial biosynthesis: promoting mitochondrial proliferation and enhanced function in muscle cells, improving energy production efficiency;

Enhancing fatty acid oxidation: promoting the consumption of fat as an energy source, reducing fat storage;

Regulating gene expression: triggering the same metabolic gene network as exercise, enhancing skeletal muscle oxidation capacity;

Improving insulin signaling: increasing cellular sensitivity to insulin, optimizing glycemic control.